2 weeks 6 days ago
People living with T1D spend a few hours a year with health-care providers, as diabetes is primarily self-managed. This burden can weigh heavily on the individual, especially for vulnerable populations. The Peer 2 Peer (P2P) mentorship program (by I Challenge Diabetes) was created to support individuals living with T1D in developing critical skills for diabetes self-management. The objective of this study was to evaluate the implementation of P2P from the mentor perspective.
KATHARINE MACKETT, MICHELLE GREENWAY, DIANA SHERIFALI, RUSSELL DE SOUZA, CHRIS JARVIS, JULIA PESEK, NANCY SANTESSO
2 weeks 6 days ago
Dietitians working in primary care (PC) treat patients with foods and nutrition issues. They are important interprofessional team members collaborating with other professionals to provide quality and equitable care to patients, including those with diabetes. However, their full scope of practice is not well known by other professionals, which can hinder collaboration in the team-based care model. The objective was to assess Canadian dietitians’ perception about interprofessional collaboration in PC, which led to the development of asynchronous virtual simulation-based learning modules to strengthen competencies.
ISABELLE GIROUX, WENDY MADARASZ, JANE TYERMAN, JACLYN ADLER, SERENA BEBER, MARY ANNE SMITH, JOIE SHAW, JOSEPH MURPHY, DENIS TSANG, ÉLIANE BOUCHARD, RAPHAËLLE LAROCHE-NANTEL
2 weeks 6 days ago
Adiposopathy is a major contributing factor for type 2 diabetes (T2D) and can result in complications. This study explored the perspectives of people with T2D regarding the value and expected impacts of reaching a lower weight.
MELISSA ROSS, SARAH MULNICK, MEREDITH HOOG, KRISTINA BOYE, CHRISTINE LONGUET, ASHLEY SAMUELSON, VIVIAN THIEU, MICHAEL VALLIS, JENNIFER GLASS
2 weeks 6 days ago
Ten years ago, the “Building Competency in Diabetes Education resource manual: Diabetes Physical Activity and Exercise” (aka “Toolkit”) was introduced to diabetes care professionals (DCPs) across Canada. The launch of this resource resulted in improvements in physical activity and exercise (PAEx)-related perceptions and practices among DCPs; however, what the status of PAE promotion is in diabetes care today is unclear. This national cross-sectional study examined the current PAEx perceptions and practices of DCPs (N=116).
CHRISTOPHER SHIELDS, KATIE RICHARDS, JONATHON FOWLES
2 weeks 6 days ago
Increased plasma low-density lipoprotein conjugated dienes (PLDL-CDs) are associated with elevated inflammation (as measured by plasma C-reactive protein [PCRP]) which exacerbates type 2 diabetes (T2D). The objective was to test the novel hypothesis that PLDL-CDs’ reduction responsiveness to antioxidant-containing flaxseed lignan complex (FLC) consumption relative to placebo would be associated with a PCRP level reduction in older type 2 diabetes patients (OT2DP).
DOUGLAS BARRE
2 weeks 6 days ago
While insulin is the main therapy for cystic fibrosis-related diabetes (CFRD), repaglinide has been an alternative. Elexacaftor-tezacaftor-ivacaftor (ETI), a modulator of the cystic fibrosis transmembrane conductance regulator, is routinely prescribed for those who are eligible. ETI and repaglinide are substrates of common hepatocyte transporters. Each drug may result in increased transaminases, causing liver toxicity. There are limited safety data regarding the use of these medications together.
MIRNA GERGES, MEREDITH CHIASSON, CARLY NICHOLS, NANCY MORRISON, SARAH SUTHERLAND, BARNA DE
2 weeks 6 days ago
Some population-based studies from Japan, Korea, and the US have suggested hearing impairment (HI, or loss of hearing acuity) as an underrecognized microvascular complication of diabetes mellitus (DM). In this study, we aimed to determine the prevalence and odds ratios (ORs) of HI among Canadians with pre-diabetes (pre-DM) and DM using the Canadian Longitudinal Study on Aging comprehensive dataset. In total, 23 749 eligible participants were categorized as either control group, group with pre-DM, or group with DM.
NHI NGUYEN, ADRIAN FUENTE
2 weeks 6 days ago
People living with type 1 diabetes (PwT1D) have a heightened concern of their body image due to weight gain that may be related to insulin administration, frequent bodyweight monitoring, and stigma. As body image dissatisfaction (BID) is associated with an elevated risk of developing an eating disorder, there is a need to accurately predict BID. Objectives: We aimed to 1) compare machine learning (ML) models (Decision Trees, Random Forest, Extreme Gradient Boosting, and K Nearest Neighbours) and evaluate their predictive performance of BID; and 2) identify important predictors.
COURTNEY SOUTH, SHAHRYAR EBRAHIMI, ANNE-SOPHIE BRAZEAU, MARIA CUTUMISU
2 weeks 6 days ago
Obesity is now recognized as a chronic disease. The Edmonton Obesity Staging System (EOSS) was suggested for the prediction of health adverse outcome among individuals with overweight/obesity. Metabolic syndrome, as defined by the National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) criteria has been linked to cardiometabolic complications, including type 2 diabetes. We aim to determine the predictive value of EOSS staging and NCEP ATP III criteria for each of all-cause, cardiovascular, and cancer-related mortality occurring before the median age of death for each of men and women in Canada among individuals with obesity enrolled in the Ottawa Hospital Weight Management Program.
BELINDA ELISHA, MAJID NIKPAY, HEATHER LOCHNAN, MARY-ELLEN HARPER, RUTH MCPHERSON, ROBERT DENT
2 weeks 6 days ago
Existing gestational diabetes mellitus (GDM) prevention programs may not adequately address the needs of Indigenous women, especially those living in urban areas where access to health-promoting traditional foods and activities may be limited. To better serve this population, their unique experiences and challenges with pregnancy, GDM, and prenatal health care must be considered.
LESLIE REDMOND, SINA SARVIHA, HALEY GROSS, JOANNA CANDAS
2 weeks 6 days ago
Primary hyperparathyroidism (PHPT), which is associated with nephrocalcinosis and nephrolithiasis, may lead to kidney dysfunction. Current clinical practice guidelines recommend young patients (<50 years) and those with PHPT-related complications, including kidney disease (defined by an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m2), be referred for parathyroidectomy. However, the impact of parathyroidectomy on longer term kidney function remains unclear. We aimed to examine the impact of parathyroidectomy on eGFR at 365 days compared to conservative management (e.g., monitoring, calcium/vitamin D supplementation, antiresorptive therapy).
IRIS LIU, DHEEPTHI THOMMANDRAM, AKSHAY VARGHESE, AHMED AL-SHAER, DEMETRI PANANOS, HEATHER LAPIER, STAN VAN UUM, TAYYAB KHAN, JOHN YOO, DANIELLE MACNEIL, KRISTIN CLEMENS
2 weeks 6 days ago
Type 2 diabetes (T2D) is associated with impaired cognition and hemodynamics. These impairments may be due to disrupted brain blood flow and neurovascular coupling. In 26 individuals with T2D and 1 with prediabetes (52% female, age 64±13years, BMI=28±5.1 kg/m2, diabetes duration=14±13years, A1C=7.0±1.5%), resting heart rate (RHR), mean arterial pressure (MAP), and cardiac output index (Qi; normalized to body surface area) were measured with a standard single-lead electrocardiogram and Finometer Pro device.
OLIVIA RAMRAJ, NATASHA ANITA, SI WON RYOO, FELICIA KWAN, WALTER SWARDFAGER, HEATHER EDGELL, SHIROPA NOOR
2 weeks 6 days ago
Beta-cell function and mass are under the control of G protein-coupled receptors (GPCRs) which are themselves subject to intracellular regulation by RGS proteins. Although the importance of GPCRs to beta-cell biology is well documented, the role of RGS proteins is largely unknown. Recent evidence suggests that RGS9 may have a role in the control of insulin secretion. This study was designed to elucidate the role and mechanism of action of RGS9 in the rodent beta cell. qPCR and RNA in situ hybridization were performed on isolated mouse islets and pancreatic sections, respectively.
SARAH FERRAGNE, SCOTT CAMPBELL, LAURA REININGER, CAROLINE TREMBLAY, JULIEN GHISLAIN, VINCENT POITOUT
2 weeks 6 days ago
Cellular senescence has been implicated in age-related tissue dysfunction, including in type 2 diabetes (T2D). Our lab has identified distinct beta-cell subsets, termed "leaders” and "hubs,” with distinct intracellular calcium dynamics and connectivity that are essential for insulin secretion. We hypothesize that senescent beta cells, marked by p21(CDKN1A), may overlap with these functionally-specialized cells.
PRISCILA CARAPETO, GIADA OSTINELLI, LUIS FERNANDO DELGADILLO-SILVA, CRISTINA AGUAYO-MAZZUCATO, GUY A. RUTTER
2 weeks 6 days ago
Objective: The purpose of this systematic review was to identify risk factors to help prevent dementia for adults living with type 2 diabetes, with links to both diseases identified, for screening, optimizing self-management, with broad impact of costs saved. No universal screening method exists for cognitive decline. Self-management of type 2 diabetes with increasing health-care costs of managing both diseases are impacted.
SUZANNE OVENDEN, ANTHONY BREITBACH
2 weeks 6 days ago
Cardiovascular (CV) risk increases in people living with metabolic dysfunction-associated steatohepatitis (MASH). Liver biopsy is the gold standard for diagnosing MASH but impractical on a large scale. However, non-invasive tests, such as Fibrosis-4 score (FIB-4), are useful for staging patients with fibrotic MASH and predict overall, CV, and liver mortality. In the SELECT trial, semaglutide reduced CV risk by 20% versus placebo. This SELECT sub-analysis assessed CV benefits of semaglutide in people at high risk of MASH.
MICHAEL TSOUKAS, SEBASTIAN M. MEYHöFER, BERTRAND CARIOU, CINTIA CERCATO, HELEN M. COLHOUN, ANNE KATRINE DUUN-HENRIKSEN, IRIS KLIERS, A. MICHAEL LINCOFF, ILDIKO LINGVAY, MICHELLE T. LONG, PHILIP NEWSOME, STEPHEN J. NICHOLLS, MARIA DE LOS ANGELES QUIROGA…
2 weeks 6 days ago
The current management of diabetes in our long-term care (LTC) setting does not meet current standards of practice for diabetes management. Continuous glucose monitors (CGM) can detect a hypoglycemic episode when it is happening, allowing for earlier treatment and a reduction in time spent hypoglycemic. Fewer episodes of hypoglycemia and less time spent hypoglycemic have been shown to reduce life-threatening emergencies, reduce the frequency of point-of-care testing (POCT), and inform treatment decisions with respect to insulin dosing.
FIONA THOMPSON-HUTCHISON, IOANA NISTORESCU, CHRIS FAN-LUN, MONA KABANI, SUSAN DEERING, ANITA LONG, ISABELLA ROSSI
2 weeks 6 days ago
Abnormal glucagon levels are a feature of both type 1 and 2 diabetes, but the basic mechanism(s) underlying the control of glucagon secretion from healthy islet α cells are still incompletely understood, despite decades of research. Hormone secretion from α, β, and δ cells are known to be triggered by changes in the cytosolic calcium concentration ([Ca2+]C). Hence, highspeed (6.25 Hz) dynamic [Ca2+]C imaging was performed in Calbryte590AM–loaded α, β, and δ cells within fresh pancreas tissue slices from male and female mice (Glu-Cre:GCaMP6fLoxP) expressing the Ca2+ sensor GCaMP6f preferentially in α cells.
YA-CHI HUANG, MARJAN SLAK RUPNIK, GUY A. RUTTER
2 weeks 6 days ago
Individuals with T1D who experience social disadvantages may have less equitable access to diabetes technologies, contributing to adverse diabetes outcomes. We evaluated associations between social disadvantage indicators and use of insulin pumps and continuous glucose monitors (CGM) in Québec, where CGM are publicly funded; however, insulin pumps are not unless initiated prior to age 18 years.
ALANNA WEISMAN, PARISA KHODABANDEHLOO, PATIENCE FAKEMBE, JOYEUSE SENGA, RAYZEL SHULMAN, LORRAINE L. LIPSCOMBE, HOLLY WITTEMAN, ANANYA BANERJEE, JUSTIN PRESSEAU, MERANDA NAKHLA, MAMAN JOYCE DOGBA, LEIF ERIK LOVBLOM, REMI RABASA-LHORET, ANNE-SOPHIE BRAZEAU
2 weeks 6 days ago
Statins are widely prescribed to lower blood cholesterol and the risk of cardiovascular events. Epidemiological data prompted Health Canada to add warning labels on all statins, indicating an increased risk of higher blood glucose and diabetes (Health Canada, RA-16949). This side effect is important since statin users often share cardiovascular and diabetes risks. Statins inhibit HMG CoA reductase, lowering cholesterol production and increasing hepatic LDL sequestration from the blood. Inhibition of HMG CoA reductase also reduces post-translational protein prenylation1 altering immunity, and providing anti-inflammatory effects independent of cholesterol-lowering.
NAZLI ROBIN, NATHALIE JOUVET, JENNIFER ESTALL, JONATHAN SCHERTZER
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