2 months 3 weeks ago
Youth living with type 2 diabetes (T2D) have identified mental health as an important factor in diabetes management. Dialectical Behavior Therapy (DBT) is an evidence-based program that includes teaching mindfulness, emotion regulation, and distress tolerance. This pilot project examines the feasibility and tolerability of virtual DBT skills training as a mental health intervention in youth with T2D.
MELISSA DEL VECCHIO, LILY PANKRATZ, EMILY CAMERON, ELIZABETH SELLERS, JONATHAN MCGAVOCK, MANDY ARCHIBALD, LINDA DIFFEY, LAURENCE KATZ, TANYA DAWN MCDOUGALL, ALLISON DART, BRANDY WICKLOW
2 months 3 weeks ago
Maternal preconception obesity, excessive gestational weight gain, and adverse metabolic health increase the risk of childhood obesity in offspring, and adverse postpartum cardiometabolic health in mothers. It remains unknown whether preconception lifestyle interventions impact offspring health in childhood. Therefore, our study aims to compare lifestyle and cardiometabolic factors in 50 mothers and their 6–10-year-old children born in the Obesity-Fertility randomized controlled trial that compared a lifestyle intervention during preconception and pregnancy in women with obesity and infertility (IG) to usual fertility care (CG).
ALEXANDRA THIBODEAU, CHRISTOPHE RICHER DIT LAFLÈCHE, FARRAH JEAN-DENIS, SOREN HARNOIS-LEBLANC, PATRICE PERRON, MARIE-EVE MATHIEU, FRÉDÉRIC DALLAIRE, ANNE-SOPHIE MORISSET, MARTIN BROCHU, JEAN-PATRICE BAILLARGEON
2 months 3 weeks ago
Glucagon-like peptide 1 receptor agonists (GLP-1RA) are effective medications for type 2 diabetes mellitus (T2DM) and obesity, yet their uptake among patients most likely to benefit from them has been slow.
PRACHI RAY, JASON MOGGRIDGE, ALANNA WEISMAN, MINA TADROUS, DANIEL DRUCKER, BRUCE PERKINS, MICHAEL FRALICK
2 months 3 weeks ago
Cystic fibrosis-related diabetes (CFRD) and impaired glucose tolerance affect up to 50% of adults with CF. CFRD is associated with accelerated lung function decline and mortality, especially in women. A new CF mouse model (B6-Tg(CFTR508del)Cwr), expressing the human F508del cftr gene, is becoming available. We conducted a study to validate B6-Tg(CFTR508del)Cwr mice as a CFRD model.
DANIEL NEIRA AGONH, KAROLINA SADOWSKA, FREDERIC CHAPPE, VALERIE CHAPPE, YOUNES ANINI
2 months 3 weeks ago
People living with type 2 diabetes (PWT2D) face nutrition constraints that may impact their food-purchasing decisions. Using mixed-methods, we combined eye-tracking data and qualitative data to evaluate the decision-making process of PWT2D in a food retail setting. Participants aged 40–65 years were recruited, including a PWT2D study group and comparison group without T2D. Eligible participants were invited to McGill’s Retail Innovation Lab (RIL) to complete a shopping task. Participants purchased 4 food products from 3 different categories (salty, sweet, beverage, and a free choice among those 3), while wearing eye-tracking glasses.
PABLO ARRONA-CARDOZA, ANNE-SOPHIE BRAZEAU, DAIVA NIELSEN
2 months 3 weeks ago
Type 2 diabetes (T2D) affects 9% of Canadians. Indigenous peoples in Canada face higher T2D incidence and poorer outcomes compared to non-Indigenous individuals. Implicit and explicit biases towards Indigenous Peoples and people with T2D in health care have been documented, impacting the quality of care they receive. This study evaluated biases of 79 health-care practitioners (HCPs) in the Interior Health region of British Columbia towards Indigenous peoples and their explicit attitudes towards people with T2D.
RENEE YOUNG, MARY E. JUNG, REBECCA REITSMA, KYRA BRAATEN
2 months 3 weeks ago
Avoiding Diabetes After Pregnancy Together with Moms (ADAPT-M) is a nutrition and physical activity coaching program that targets modifiable risk factors for type 2 diabetes among women with a history of gestational diabetes mellitus (GDM). Evidence indicates that postpartum lifestyle modification can prevent diabetes after GDM, and a pilot randomized trial showed high feasibility, uptake, and satisfaction with the program. Thus, pre-implementation strategies are underway to implement the program at 3 settings in Ontario, Canada.
KATELYN SUSHKO, DIANA SHERIFALI, LORRAINE L. LIPSCOMBE
2 months 3 weeks ago
Understanding the relationship between circulating biomarkers and body composition measurements is crucial to improve the prediction of health outcomes after weight loss intervention. This study aims at identifying independent biomarkers associated with 6 body composition measurements from bioimpedance (namely trunk fat mass [FM], arm FM, leg FM, trunk fat-free mass [FFM], arm FFM, and leg FFM) among a panel of 1,463 circulating biomarker levels measured using the Proximity Extension Assay (PEA) technology, in a subset of 50,673 adult individuals of European descent from the UK Biobank.
DEJVIT HAMZARAJ, JAMES FEINER, KEONA PANG, GUILLAUME PARE, MARIE PIGEYRE
2 months 3 weeks ago
There is a need to assess the impact of virtual care in diabetes in pregnancy (DIP) clinics given a recent increase in virtual care use. The objective of this study was to compare maternal and neonatal outcomes between individuals with gestational diabetes (GDM) treated with virtual care versus standard in-person care. A retrospective cohort study was performed of individuals with GDM that attended interdisciplinary DIP clinics in Calgary between 2017–2022. The primary exposure was visit modality for the initial appointment with a diabetes educator.
SAMIN DOLATABADI, JENNIFER YAMAMOTO, ERIN BRENNAND, LOIS DONOVAN, JAMIE BENHAM
2 months 3 weeks ago
Type 2 diabetes (T2D) is one of the fastest growing chronic pediatric conditions in Canada. The bio-psycho-social factors involved in the etiology, treatment, and prevention of pediatric T2D are unique relative to adult-onset T2D. Few studies exist describing the scientific approaches to studying mechanisms, prevention, and treatment of pediatric T2D.
JANA SLAGHT, STEPHANIE MANTHANARACK, ALLISON DART, VERNON DOLINSKY, JONATHAN MCGAVOCK
2 months 3 weeks ago
Youth with T2D have high rates of ambulatory hypertension. We hypothesize that prevalence of hypertension will be higher according to the new AHA 2022 ABPM guidelines, with a greater association to clinical measures of cardiorenal complications.
HARMAN KAUR VATS, ALLISON DART, RAHUL CHANCHLANI, BRANDY WICKLOW, ELIZABETH SELLERS, JONATHAN MCGAVOCK, MELISSA DEL VECCHIO
2 months 3 weeks ago
By May 31, 2024, no more than 25 patients per day will be booked into follow-up clinics at the RCH Diabetes and Pregnancy Clinic.
JENNIFER KLINKE
2 months 3 weeks ago
Food insecurity is an inadequate access to food due to financial constraints. It is more prevalent in families of children with diabetes, compared to the general population in Nova Scotia. It is also associated with an increased risk of diabetes complications (ketoacidosis, hospital admissions, and long-term consequences). We aimed to identify barriers and facilitators to discussing food security (FS) status, and to improve clinic processes to identify and support food insecure families.
MARA MCNEIL, ELIZABETH CUMMINGS
2 months 3 weeks ago
Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease (CVD). We have shown high-risk young women aged 18–45 years with and without PCOS exhibit atherogenic dyslipidemia and increased atherosclerotic CVD (ACVD), compared to healthy-weight controls. In those with PCOS, the grading of ACVD is more adverse, inclusive of carotid plaque height (CPH) and carotid intimal medial thickness (CIMT). The aim of this study was to determine the natural history and progression of ACVD in young women with and without PCOS.
XIAOYING WU, MAHUA GHOSH, PAOLO RAGGI, HARALD BECHER, DONNA VINE
2 months 3 weeks ago
To respond to the Truth and Reconciliation call to action #19 by describing trends in inequities in cardiovascular disease (CVD) and several structural determinants of health among First Nations adults living in Winnipeg.
MONECA SINCLAIRE, KEVIN FRIESEN, HEATHER PRIOR, JONATHAN MCGAVOCK
2 months 3 weeks ago
Lack of attachment to a regular primary care provider (PCP) is a problem across Canada and a concern for people with diabetes. In Nova Scotia, people self-identify as having diabetes on the Need a Family Practice Registry (NFPR). We aimed to determine the scope of the problem, increase system capacity to deliver diabetes care, and increase access to that care for adults without a PCP.
KRISTIN CURRIE, PAM TALBOT, CHRISTINE TOMPKINS
2 months 3 weeks ago
Continuous subcutaneous insulin infusion (CSII) in type 1 diabetes has been regarded as a major diabetic ketoacidosis (DKA) risk factor. We aimed to determine secular trends in DKA risk since CSII implementation in the 1980s.
DALTON BUDHRAM, PRIYA BAPAT, ABDULMOHSEN BAKHSH, MOHAMMAD ABUABAT, NATASHA VERHOEFF, DOUG MUMFORD, WAJEEHA CHEEMA, ANDREJ ORSZAG, AKSHAY JAIN, DAVID CHERNEY, MICHAEL FRALICK, BADER ALAMRI, ALANNA WEISMAN, LEIF ERIK LOVBLOM, BRUCE PERKINS
2 months 3 weeks ago
This study aimed to investigate the effects of intensive phone call diabetes self-management education (DSME) interventions on self-management behaviours and metabolic outcomes in individuals with type 2 diabetes.
LIFENG FAN
2 months 3 weeks ago
Age at diagnosis and medical trauma play important roles in how people living with type 1 diabetes (T1D) experience and interact with health care. The aim of this study was to assess how age at diagnosis and past experiences of medical trauma impact how people living with T1D perceive and seek future care.
JAMIE BOISVENUE, YOUSSEF ELEZZABI, KATHLEEN GIBSON, KIM YOUNG, PETER SENIOR, ROSEANNE YEUNG
2 months 3 weeks ago
Cardiometabolic diseases like atherosclerosis, liver steatosis, and type 2 diabetes (T2D) are characterized by vascular inflammation and dysregulated lipid metabolism. Lifestyle interventions, like the Diabetes Canada-approved ketogenic diet (KD), are first-line treatments for cardiometabolic disease. The KD is an extremely high-fat (>70% kcal), low- carbohydrate (< 10% kcal) diet that, in people, often raises cholesterol but reduces body weight and improves glycemia. T2D, obesity, and cardiovascular disease are associated with increased circulating dipeptidyl-peptidase 4 (DPP4) concentration and activity.
CASSANDRA LOCATELLI, MY-AHN NGUYEN, NATASHA TRZASKALSKI, NADYA MORROW, ARIANNE MORISSETTE, ERIN MULVIHILL
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