3 days 5 hours ago
Gestational diabetes mellitus (GDM) increases future risks of type 2 diabetes and cardiovascular disease. Despite Diabetes Canada guidelines recommending postpartum glucose testing following GDM, uptake remains low. Canadian population-based studies are needed to examine systems-level factors affecting uptake.
Kathleen Baker, Nikki Stephenson, Colleen Cuthbert, Doreen Rabi, Amy Metcalfe
5 days 5 hours ago
This study explores the link between circulating vitamin C levels and the risk of diabetes mellitus (DM) using data from the National Health and Nutrition Examination Survey (NHANES) for the cycles of 2003-2004, 2005-2006, and 2017-2018. Our analysis revealed a significant inverse relationship, showing that higher levels of vitamin C are associated with a reduced risk of DM. Specifically, higher vitamin C concentrations correlated with lower odds of DM, particularly at elevated quartile levels. Despite these findings, Mendelian randomization (MR) analysis did not establish a causal link between vitamin C and type 1 diabetes (T1DM).
Zhitong Li, Jinchang Liu, Xingyu Li, Shiwei Liu
1 week 6 days ago
People with diabetes are vulnerable to health inequities and population level COVID-19 vaccine uptake among adults with diabetes is unknown. Our aim was to assess COVID-19 vaccine uptake among adults with and without diabetes and the factors associated with vaccination.
Sonia Butalia, Ronald J. Sigal, Baiju R. Shah, Jamie L. Benham, Brandy Wicklow, Catherine H. Yu, Kaberi Dasgupta, Luan M. Chu, Shazhan Amed, Cora Constantinescu, Padma Kaul
2 weeks 2 days ago
To explore adolescents' experiences of T2D, particularly concerning (1) diagnosis and management and (2) emotional wellbeing.
Gitanjali Subramani, Alexia S. Peña, Melissa Oxlad
2 weeks 6 days ago
The South Asian population is rapidly growing in the Greater Toronto Area with a growth rate of 10.6% versus the national average of 5.2%. Diabetes disproportionately affects South Asians, 8.1 times higher compared to Caucasians with increased risk of macrovascular and microvascular complications. There are several risk factors that have been identified including 24 single nucleotide polymorphisms, higher insulin resistance, low mean skeletal mass with higher visceral fat, and socioeconomic and family stressors.
Anjali Thomas, Nirojini Sivachandran
3 weeks 6 days ago
Children and youth with type 1 diabetes (T1D) must have support to manage their condition at school. In 2017, Ontario students and their parents were surveyed to assess the level of school support and the extent to which that support met perceived needs. In 2018 a provincial policy was established, providing high level guidance regarding children with T1D in school. We redistributed our survey in 2023 to determine whether support for children with T1D has improved and where gaps remain.
Hannah Geddie, Ereny Bassilious, Myanca Rodrigues, Elizabeth Moreau, Mark R. Palmert, Sarah E. Lawrence
4 weeks 2 days ago
To determine the contemporary annual incidence rates of hospitalization for diabetes-related foot complication (DFC) and lower-extremity amputation in Canada.
Angela Y. Kim, James Hanley, Rebecca Fuhrer, Charles de Mestral
1 month ago
Diabetic foot ulcer (DFU), a complication of diabetes, is associated with an increased risk of major amputation and mortality. However, the underlying pathogenesis of DFU remains unclear. The goal of this study was to investigate the role and underlying mechanism of MAF bZIP transcription factor G (MAFG) in DFU wound healing.
Jiasi Huang, Ye Peng, Yihui Xiao, Yan Wang, Fangxing Hu
1 month 1 week ago
Diabetes self-management often occurs in social contexts, around others without diabetes. International consensus identifies the pervasive presence of social stigma toward those with diabetes, negatively impacting health, well-being, and social and professional lives. In this study we aimed to identify the social experiences of Canadian adults living with type 1 diabetes (T1D) or type 2 diabetes (T2D).
Michael Vallis, J.J. Bresolin, Kim Fletcher, Elizabeth Holmes-Truscott, Jane Speight, Laura Syron
1 month 2 weeks ago
Denise Montt-Blanchard, Franco Giraudo, Raimundo Sánchez
1 month 2 weeks ago
There are high-quality data demonstrating improved pregnancy outcomes with gestational diabetes mellitus (GDM) treatment [1]. Thus, screening for and treatment of GDM is recommended by clinical practice guidelines around the world [2]. Although controversy remains regarding the optimal screening recommendations, both who should be screened and which glucose test and level cut-offs should be used, most international guideline recommendations include dynamic glucose testing, such as the 75- or 100-g oral glucose tolerance test (OGTT) with or without a preceding 50-g glucose challenge [3].
Jamie L. Benham, Nikki Stephenson, Amy Metcalfe, Lois E. Donovan, Denice S. Feig, Christy Pylylpjuk, Chelsea Ruth, Howard Berger, Sarah M. Sigurdson, Baiju R. Shah, Jennifer M. Yamamoto
1 month 2 weeks ago
Diabetes care in Canada is compromised by the lack of resources to adequately address the mental health challenges associated with both type 1 and type 2 diabetes. To address this gap Breakthrough T1D (formerly JDRF) Canada and Diabetes Canada developed a bilingual training program, and associated directory listing successful graduates, to educate and empower existing mental health providers to better provide services to those living with diabetes. This study reports on the development and initial outcomes of this virtual training program.
Tricia S. Tang, Jessica C. Kichler, Zosia R. Anders, Marie Raffray, Tiffany R. Shepherd, Brandi A. Wicklow, Julia Bannister, Mona Gupta, Amanda M. Hailman, Gerri M. Klein, Joanne Lewis, Sarah E. Linklater, Sadinand D. Mankikar, Caleb Pope, Katie D. Ryan,…
2 months ago
Khan et al have responded to our recent publication on the development of a patient-reported outcome measure to assess the impact of continuous glucose monitoring (CGM) devices on diabetes self-management [1]. The authors have raise several important issues regarding our work. First, they noted that all data on the impact of CGM use on capability, opportunity, and motivation to self-manage diabetes are self-report data. Importantly, as stated by the authors, self-report is subject to social desirability bias.
Michael Vallis, Lori Berard, Emmanuel Cosson, Finn Boerlum Kristensen, Fleur Levrat-Guillen, Nicolas Naiditch, Remi Rabasa-Lhoret, William Polonsky
2 months ago
A 51-year-old woman with type 1 diabetes, hypertension, and hypothyroidism visited the emergency department (ED) with excessive nausea and vomiting. At presentation, her serum glucose was 28.5 mmol/L, glycated hemoglobin (A1C) was 8.0%, and beta-hydroxybutyrate was 4.2 mmol/L (normal 0.6 mmol/L), with an increased anion gap of 18.8 mEq/L (normal 4 to 12 mEq/L). Arterial blood gas showed that pH was 7.53 and bicarbonate was 18.6 mEq/L. Urine drug screen was positive for cannabis. Past medical history was notable for type 1 diabetes for 12 years with mild diabetic retinopathy.
Kagan E. Karakus, Halis K. Akturk
2 months 1 week ago
Immune-Inflammation plays a crucial role in the pathogenesis of diabetic kidney disease (DKD), but the exact assessment of indicators are undefined. Our paper examined the link between Systemic immune-inflammation index (SII) and mortality risk in DKD, and explore the effect of sex disparities on it.
Yun She, Xiangyun Guo, Ying Tan, Qingqing Liu, Lingling Zhu, Xiqiao Zhou, Jiangyi Yu, Qianhua Yan
2 months 1 week ago
Patient decision aids (PtDAs) are evidence-based interventions to help people faced with difficult health-care decisions. Little is known about their effectiveness in people facing diabetes-related decisions. The aim of this study was to evaluate the scope and effectiveness of diabetes-related PtDAs for screening, prevention, and treatment decisions.
Sandhya Goge, Christopher Tran, Krystina B. Lewis, Meg Carley, Carol Bennett, Dawn Stacey
2 months 1 week ago
The benefits of exercise and physical activity (PA) for people living with diabetes are clear. However, current exercise recommendations do not take into consideration the potential impact of female-specific hormonal changes across the lifespan on the glycemic response to exercise. Moreover, the impact of life phases on barriers to participation in exercise and PA for women compared to men with diabetes is not well described. In this narrative review we have synthesized the literature to date regarding the interaction of female sex hormone variations (menarche and the menstrual cycle, pregnancy, and the menopausal transition) with glycemic management in the context of exercise for females with type 1 and type 2 diabetes.
Tricia M. Peters, Anne-Sophie Brazeau, Lia Bally, Alexa Govette, Elsa Heyman, Mary E. Jung, Céline I. Laesser, Élodie Lespagnol, Jessica E. Logan, Zeinab Momeni, Tawnya Perry, Meryem K. Talbo, Anne Bonhoure, Jenna A.P. Sim, Jasmin von Zezschwitz, Dessi P…
2 months 1 week ago
Regular physical activity is a key, patient-centred therapy for people with diabetes to manage their glycaemia. The International Working Group on the Diabetic Foot (IWGDF) recommends optimisation of glycaemic control for people with/at risk of diabetes-related foot ulcer (DFU), however people with DFU are commonly instructed by clinicians to avoid physical activity so as not to worsen the ulcer. The effects of exercise on glycaemia, fitness, and wound healing in people with active DFU are not clear.
Callum J. Baker, Vivienne Chuter, Magali Brousseau-Foley, Danqing Min, Angela Searle, Stephen M. Twigg, Nathan A. Johnson
2 months 2 weeks ago
This updated clinical practice guideline replaces the previous chapter of Glycemic Management in Adults With Type 1 Diabetes (2018, chapter 12) and updates the glycemic management portions of the Management of Type 1 Diabetes in Children and Adolescents chapter (2018, chapter 34) where new evidence impacting clinical practice has become available. The term children is inclusive of all individuals <18 years of age, whereas evidence specific to adolescents indicates 13–18 years and toddlers <4 years.
Ilana J. Halperin, Brandy Wicklow, Shazhan Amed, Alanna Chambers, Charlotte Courage, Elizabeth Cummings, Patricia Kirkland, Dylan MacKay, Meranda Nakhla, Zubin Punthakee, Paul M. Ryan, Lindsay Sawatsky, Peter A. Senior, Bikrampal S. Sidhu, Alanna Weisman…
2 months 2 weeks ago
We appreciate the perspectives shared by Trinacty and Goldenberg about the 2024 update to the Pharmacologic Glycemic Management of Type 2 Diabetes in Adults chapter of the Diabetes Canada Clinical Practice Guidelines [1]. Our recommendation to continue to prioritize metformin as first-line therapy for most people with type 2 diabetes is based on a rigorous review of the evidence, and we welcome this opportunity to further detail the rationale underpinning this recommendation.
Baiju R. Shah, Harpreet S. Bajaj, Sonia Butalia, Kaberi Dasgupta, Dean T. Eurich, Rahul Jain, Kerry Mansell, Scot Simpson
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1 hour 59 minutes ago
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